منابع مشابه
Anthrax: A motor protein determines anthrax susceptibility
A new study has found that polymorphisms in the host gene kif1C, which encodes a kinesin-like motor protein, determine whether mouse macrophages are resistant or sensitive to anthrax lethal toxin. These findings may lead the way to discovering how both germ and host factors might contribute to a lethal infection.
متن کاملAnthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages.
Toxins play a major role in the pathogenesis of Bacillus anthracis by subverting the host defenses. However, besides toxins, B. anthracis expresses effector proteins, whose role in pathogenesis are yet to be investigated. Here we present that suppressor-of-variegation, enhancer-of-zeste, trithorax protein from B. anthracis (BaSET) methylates human histone H1, resulting in repression of NF-κB fu...
متن کاملAnthrax.
Anthrax is an often fatal bacterial infection that occurs when Bacillus anthracis endospores enter the body through one of three major routes: inhalational, cutaneous, or gastrointestinal. Before the anthrax terrorist attacks in the United States in 2001, there was very little interest in anthrax as a serious human pathogen; anthrax was viewed mainly as a veterinarian problem of minor importanc...
متن کامل[Anthrax].
Having dwelled on the etiopathogenetic, pathologic, and clinical features of human infections caused by B. anthracis, the authors review and analyze epidemiological data of the cases of anthrax registered in Italy during the last ten years. Actual possibilities for prevention are evaluated in view of the fact that enzootic foci still exist in our country which are clearly responsible for the ty...
متن کاملProton-coupled protein transport through the anthrax toxin channel.
Anthrax toxin consists of three proteins (approx. 90kDa each): lethal factor (LF); oedema factor (OF); and protective antigen (PA). The former two are enzymes that act when they reach the cytosol of a targeted cell. To enter the cytosol, however, which they do after being endocytosed into an acidic vesicle compartment, they require the third component, PA. PA (or rather its proteolytically gene...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.467696